成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>1638241-89-0

1638241-89-0

中文名稱 1638241-89-0
英文名稱 STING-Inducer-1
CAS 1638241-89-0
分子式 C20H24N10O10P2S2
分子量 690.54
MOL 文件 1638241-89-0.mol
更新日期 2024/11/15 18:20:32
1638241-89-0 結(jié)構(gòu)式 1638241-89-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T10252L3
MIW815
ML RR-S2 CDA
英文別名
MIW815
ML RR-S2 CDA
STING-Inducer-1
ML RR-S2 CDA
MIW815
STING-INDUCER-1
ML RR-S2 CDA
STING-INDUCER-1
1638241-89-0
Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide

物理化學(xué)性質(zhì)

沸點(diǎn)1020.8±75.0 °C(Predicted)
密度2.43±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 2 mg/mL (2.90 mM)
酸度系數(shù)(pKa)-0.67±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
InChIKeyIZJJFUQKKZFVLH-UUXHIKLWNA-N

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338

常見(jiàn)問(wèn)題列表

生物活性
ADU-S100 (MIW815) 是干擾素基因刺激物的激活劑 (STING),具有有效的抗腫瘤和免疫活性。
靶點(diǎn)

STING

體外研究

ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.

體內(nèi)研究

ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.

"1638241-89-0" 相關(guān)產(chǎn)品信息