1627843-95-1
1627843-95-1 結(jié)構(gòu)式
基本信息
英文別名
PH11Benzoic acid, 2-[[4-[(3,4,5-trimethoxyphenyl)amino]imidazo[1,2-a]-1,3,5-triazin-2-yl]amino]-, methyl ester
應(yīng)用領(lǐng)域
用途一
PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.