1607837-31-9
中文名稱
CCT251921
英文名稱
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
CAS
1607837-31-9
分子式
C21H23ClN6O
分子量
410.9
MOL 文件
1607837-31-9.mol
更新日期
2023/03/20 15:41:27
1607837-31-9 結(jié)構(gòu)式
基本信息
中文別名
化合物CCT-251921CDK8抑制劑(CCT-251921)
英文別名
CCT-251921LM-3860,CCT251921
CCT-251921
CCT 251921
8-[2-amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-2,8-Diazaspiro[4.5]decan-1-one
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
2,8-Diazaspiro[4.5]decan-1-one, 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-
所屬類別
生物化工：生化試劑物理化學(xué)性質(zhì)
沸點696.4±55.0 °C(Predicted)
密度1.51±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : ≥ 28 mg/mL (68.14 mM)
酸度系數(shù)(pKa)15.81±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). CCT251921 showed the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer. The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.