156965-15-0
156965-15-0 結(jié)構(gòu)式
基本信息
中文別名
膽鈣化醇雜質(zhì)21(維生素D3雜質(zhì)21) 英文別名
ZK-15922ZK 159222
SPARTCPUGRJFRS-PBDCIXLPSA-N
Cholecalciferol Impurity 21
Cyclopropanecarboxylic acid, 1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]-, butyl ester
物理化學(xué)性質(zhì)
熔點(diǎn)>62°C (dec.)
沸點(diǎn)646.3±55.0 °C(Predicted)
密度1.13±0.1 g/cm3(Predicted)
儲(chǔ)存條件Amber Vial, -86°C Freezer, Under inert atmosphere
溶解度可溶于氯仿（少許）、乙酸乙酯（少許）、甲醇（少許）
酸度系數(shù)(pKa)14.29±0.20(Predicted)
形態(tài)固體
顏色灰白色至淺灰色
穩(wěn)定性對(duì)光敏感、對(duì)溫度敏感
常見問(wèn)題列表
生物活性
ZK159222 是 1α,25-(OH)2D3 的類似物，是有效的 1α,25-(OH)2D3 受體 (VDR) 拮抗劑。ZK159222 拮抗作用的機(jī)制是由配體誘導(dǎo)的維生素 D 受體與輔助激活劑的相互作用缺乏所介導(dǎo)的。ZK159222 具有部分激動(dòng)性。體外研究
ZK159222, displayed the profile of a weak VDR agonists that requires an approximate 7-fold higher concentration than of the natural hormone 1α,25-(OH)2D3?to stabilize VDR-RXR heterodimer complex formation on a DR3-type VDRE. ZK159222 was found to belong to the category of 1α,25-(OH)2D3?analogues that stabilize an additional third functional VDR conformation, which has also been described for some agonistic 20-epi analogues. The remaining reporter gene activity that was obtained by a combined treatment of 10 nM?1α,25-(OH)2D3 with 1 μM?ZK159222 is close to the partial agonistic activity of 1 μM?ZK159222.