1566-81-0
1566-81-0 結(jié)構(gòu)式
基本信息
Benzoic acid, 2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-100244 | NS1652 NS1652 | 1566-81-0 | 1mg | 1000元 |
| 2024/11/08 | HY-100244 | NS1652 NS1652 | 1566-81-0 | 5mg | 2200元 |
| 2024/11/08 | HY-100244 | NS1652 NS1652 | 1566-81-0 | 10mg | 3500元 |
常見問題列表
IC50: 1.6 μM (chloride channel, human and mouse red blood cell)
NS1652 potently inhibits the chloride conductance (IC 50 , 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC 50 , 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production with an IC 50 of 3.1 μM in BV2 cells. NS1652 also down-regulates iNOS expression at 3 μM, and completely abolishes at 10 μM in BV2 cells. NS1652 (0, 1.0, 3.3, 10, and 20 μM) causes increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h. NS1652 (20 μM) completely and reversiblely inhibits the red cell Cl - conductance.
NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl - conductance by >90% in mice.