成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>154447-38-8

154447-38-8

中文名稱 8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮
英文名稱 LY 303511
CAS 154447-38-8
分子式 C19H18N2O2
分子量 306.36
MOL 文件 154447-38-8.mol
更新日期 2024/06/20 21:07:17
154447-38-8 結(jié)構(gòu)式 154447-38-8 結(jié)構(gòu)式

基本信息

中文別名
8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮
英文別名
LY303511, >=98%
LY-303511(Nv-128)
LY 303511
LY303511
8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one
2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-
8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one LY303511

物理化學性質(zhì)

沸點496.1±45.0 °C(Predicted)
密度1.237±0.06 g/cm3(Predicted)
儲存條件Store at +4°C
溶解度Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
酸度系數(shù)(pKa)9.20±0.10(Predicted)
形態(tài)琥珀色固體

常見問題列表

生物活性
LY303511 是 LY294002 的一種結(jié)構(gòu)類似物,但 LY303511 不抑制 PI3K。LY303511 可增強 SHEP-1 神經(jīng)母細胞瘤細胞的TRAIL 敏感性。LY303511 可逆地阻斷 MIN6 胰島瘤細胞中的 K+ 電流 (IC50=64.6±9.1 μM)。
靶點

TRAIL
IC50: 64.6±9.1 μM (K + currents, in MIN6 insulinoma cells)

體外研究

LY303511 is structurally identical to LY294002 except for a substitution of -O for -NH in the morpholine ring, and does not potently inhibit PI3K. Treatment of cells with LY303511 causes an increase in calcein spread similar to levels of LY294002. The ability of LY303511 to increase gap junctional intercellular communication (GJIC) does not occur concomitant with inhibition of phosphorylation of AKT as measured by immunoblotting. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via H 2 O 2 -MAPK activation and up-regulation of death receptors. SHEP-1 cells are exposed to varying concentrations of LY303511 (LY30), TRAIL, and a combination of the two (1 h preincubation with LY303511 followed by TRAIL for 4 hours). SHEP-1 cells are responsive to TRAIL (~10%, ~15%, and ~30% reduction in the surviving fraction at 25, 50, and 100 ng/mL, respectively); however, treatment with LY303511 (12.5, 25, or 50 μM) has no effect on cell viability. However, incubation of cells with LY303511 (25 μM) for 1 hour followed by 4 hours exposure to 50 ng/mL of TRAIL has a strong synergistic effect (~40% reduction in viable cells with LY303511+TRAIL versus ~15% with TRAIL alone). LY303511 is a negative control compound with respect to PI3K activity. In MIN6 insulinoma cells, Wortmannin (100 nM) has no effect on whole-cell outward K + currents, but LY294002 and LY303511 reversibly block currents in a dose-dependent manner (IC 50 =9.0±0.7 μM and 64.6±9.1 μM, respectively). Kv2.1 and Kv1.4 are highly expressed in beta-cells, and in Kv2.1-transfected tsA201 cells, 50 μM LY294002 and 100 μM LY303511 reversibly inhibit currents by 99% and 41%, respectively. LY303511 blocks currents with an IC 50 of 64.6±9.1 μM, with a maximal inhibition of ~90% at 500 μM (n≥5 cells at each concentration).

體內(nèi)研究

Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm 3 , at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo.

"154447-38-8" 相關產(chǎn)品信息
75-31-0 102-56-7 57260-71-6