154355-75-6
中文名稱(chēng)
154355-75-6
英文名稱(chēng)
ATRELEUTON
CAS
154355-75-6
分子式
C16H15FN2O2S
分子量
318.37
MOL 文件
154355-75-6.mol
154355-75-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13263 英文別名
ATRELEUTONCOX/5-LO-IN-1
Atreleuton analog
Urea, N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-
物理化學(xué)性質(zhì)
沸點(diǎn)506.7±60.0 °C(Predicted)
密度1.37±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.63±0.50(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
COX/5-LO-IN-1 (Atreleuton analog) 是 cylooxygenase 和 5-lipoxygenase (5-LO) 的抑制劑，用于炎癥性和過(guò)敏性疾病的研究。靶點(diǎn)
|
5-LO 2 μM (IC 50 ) |
COX
|
體外研究
COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC 50 of 0.2 μM in human whole blood.