152831-36-2
152831-36-2 結(jié)構(gòu)式
基本信息
中文別名
化合物NE 10790 英文別名
3-PEHPCNE 10790
NE 10790 (3-PEHPC)
FJVYPXVLXQXDHM-UHFFFAOYSA-N
NE 10790 (Synonyms: 3-PEHPC)
3-Pyridinepropanoic acid, α-hydroxy-α-phosphono-
2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid
物理化學(xué)性質(zhì)
沸點(diǎn)583.6±60.0 °C(Predicted)
密度1.724±0.06 g/cm3(Predicted)
儲存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度Water:5.0(Max Conc. mg/mL);20.2(Max Conc. mM)
酸度系數(shù)(pKa)1.73±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
NE 10790 是法尼焦磷酸 (FPP) 合成酶的弱抑制劑，是有效的二磷酸利塞磷酸鹽的磷酸酯類似物，也是一種弱的抗吸收劑。靶點(diǎn)
FPP synthase.
體外研究
NE 10790 inhibits incorporation of [ 14 C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I.