成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>152721-37-4

152721-37-4

中文名稱(chēng) EF-5
英文名稱(chēng) EF-5
CAS 152721-37-4
分子式 C8H7F5N4O3
分子量 302.16
MOL 文件 152721-37-4.mol
152721-37-4 結(jié)構(gòu)式 152721-37-4 結(jié)構(gòu)式

基本信息

中文別名
化合物EF-5
英文別名
EF-5
EF5 >=98% (HPLC)
1H-Imidazole-1-acetamide, 2-nitro-N-(2,2,3,3,3-pentafluoropropyl)-

物理化學(xué)性質(zhì)

密度1.66±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 125 mg/mL (413.69 mM)
酸度系數(shù)(pKa)12.32±0.46(Predicted)
形態(tài)Solid
顏色White to off-white

圖譜信息

EF-5價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/08/19HY-U00118EF-5
EF-5
152721-37-45mg900元
2024/08/19HY-U00118EF-5
EF-5
152721-37-410mM * 1mLin DMSO990元
2024/08/19HY-U00118EF-5
EF-5
152721-37-410mg1500元

常見(jiàn)問(wèn)題列表

生物活性
EF-5 (EF5; 2-Nitroimidazole) 是用于鑒定細(xì)胞缺氧的缺氧標(biāo)記試劑。
體外研究

Overexpression of CYPOR induces similar 2- to 4-fold increases in EF-5 binding and metabolic reduction of tirapazamine and CEN-209 in SiHa and HCT116 cell lines, and similar enhancement of γH2AX formation. EF-5 binding and metabolic reduction of the prodrugs are highly correlated in a panel of 14 hypoxic tumor cell lines.

體內(nèi)研究

EF-5 binding is a promising stratification biomarker for benzotriazine-N-oxide bioreductive prodrugs. In HCT116 xenografts, CYPOR overexpression also significantly increases EF-5 binding and CEN-209 reduction, and modification of tumor hypoxia causes similar changes to the bioreductive activation of both agents, resulting in a strong correlation between EF-5 binding and CEN209-induced DNA damage at the individual tumor level. Following intravenous injection of EF-5, binding and detection using a monoclonal antibody in 9L gliomas is specific and oxygen dependent. Detection of binding using fluorescence microscopy can be performed on frozen tissues; tissue sections can be counterstained with haematoxylin and eosin for light microscopic analysis. Alternatively, the distribution of hypoxia in a tumor can be inferred by examining individual tumor cells using flow cytometric techniques.

"152721-37-4" 相關(guān)產(chǎn)品信息