152633-54-0
152633-54-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13340 英文別名
WIN 620052H-Imidazo[4,5-b]pyridin-2-one, 1,3-dihydro-5-methyl-6-(4-pyridinyl)-
物理化學(xué)性質(zhì)
密度1.45±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)7.36±0.60(Predicted)
常見問題列表
生物活性
Win-62005是一種環(huán)狀A(yù)MP磷酸二酯酶III (PDE III) 抑制劑，對(duì)于大鼠心臟和犬主動(dòng)脈的 Ki 值分別為25和26 nM。靶點(diǎn)
Ki: 25 nM (PDE III), 25 nM (PDE III)
體外研究
Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with K i values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes.
體內(nèi)研究
After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h.