1496088-76-6
中文名稱
化合物 T28847
英文名稱
Cyclohexanecarboxamide, 3-amino-N-1H-indazol-5-yl-
CAS
1496088-76-6
分子式
C14H18N4O
分子量
258.32
MOL 文件
1496088-76-6.mol
1496088-76-6 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
SR-17398 is a Unc-51-Like Kinase 1 (ULK1) inhibitor (IC50; 22.4 uM). Small molecule inhibition of ULK1 potentially provides an avenue for suppressing autophagy. Autophagy is protective for cancers experiencing a decrease in nutrient availability or damage caused by cancer therapeutics.9,10 Accordingly, blocking autophagy via small molecule inhibitors in autophagy-reliant cancers could increase the efficacy of current chemotherapeutics and may result in tumor suppression as a standalone chemotherapy.