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14930-96-2

中文名稱 細(xì)胞松弛素 B
英文名稱 CYTOCHALASIN B
CAS 14930-96-2
分子式 C29H37NO5
分子量 479.61
MOL 文件 14930-96-2.mol
更新日期 2024/04/26 14:05:51
14930-96-2 結(jié)構(gòu)式 14930-96-2 結(jié)構(gòu)式

基本信息

中文別名
松胞素B
松胞菌素B
細(xì)胞松馳素B
細(xì)胞松弛素B
細(xì)胞松弛素 B
細(xì)胞分裂抑素B
細(xì)胞松弛素 B 來(lái)源于長(zhǎng)蠕孢菌
CYTOCHALASIN B 細(xì)胞松弛素B
細(xì)胞松弛素 B 來(lái)源于DRECHSLERA DEMATIOIDEA
英文別名
PHOMIN
-23-one
cytochalasin
CYTOCHALACINB
CYTOCHALICINB
CYTOCHALASIN B
CYTOCHALASIN B(RG)
(7s,13e,16r,20r,21e)-0-phenyl
CYTOCHALASIN B SYNTHETIC >97%
9r,12as,13s,15s,15as,16as,18as)-5
所屬類別
原料藥:其它抗生素類藥

物理化學(xué)性質(zhì)

熔點(diǎn)218-223 °C
熔點(diǎn)218-223 °C
沸點(diǎn)577.96°C (rough estimate)
密度1.1490 (rough estimate)
折射率1.6290 (estimate)
閃點(diǎn)85℃
儲(chǔ)存條件−20°C
儲(chǔ)存條件-20°C
溶解度ethanol: 20 mg/mL
溶解度乙醇:20 mg/mL
酸度系數(shù)(pKa)13.60±0.70(Predicted)
形態(tài)powder
顏色white
Merck13,2819
BRN1096207
穩(wěn)定性從購(gòu)買之日起 2 年內(nèi)保持穩(wěn)定。 DMSO 溶液可在 -20°C 下保存長(zhǎng)達(dá) 1 個(gè)月。
InChIKeyUXVDBQLLXVKPRS-UZBFCAAUSA-N
LogP3.370

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H300+H310+H330-H361
危險(xiǎn)品標(biāo)志T+,T
危險(xiǎn)類別碼26/27/28-63-23/24/25
危險(xiǎn)類別碼26/27/28-63-23/24/25
安全說(shuō)明28-36/37-45
安全說(shuō)明28-36/37-45
危險(xiǎn)品運(yùn)輸編號(hào)UN 1544 6.1/PG 2
危險(xiǎn)品運(yùn)輸編號(hào)UN 1544 6.1/PG 2
WGK Germany3
WGK Germany3
RTECS號(hào)RO0205000
危險(xiǎn)等級(jí)6.1(a)
包裝類別I
海關(guān)編碼29349990
毒害物質(zhì)數(shù)據(jù)14930-96-2(Hazardous Substances Data)
毒性LD50 intraperitoneal in mouse: 30mg/kg

應(yīng)用領(lǐng)域

用途1
第一個(gè)用于研究細(xì)胞骨架的藥物,它是真菌分泌的生物堿。細(xì)胞松弛素(細(xì)胞松弛素B及其衍生物)在細(xì)胞內(nèi)同微絲的正端結(jié)合, 并引起F-肌動(dòng)蛋白解聚,阻斷亞基的進(jìn)一步聚合。當(dāng)將細(xì)胞松弛素加入到活細(xì)胞后,肌動(dòng)蛋白纖維骨架消失,使動(dòng)物細(xì)胞的各種活動(dòng)癱瘓, 包括細(xì)胞的移動(dòng)、吞噬作用、胞質(zhì)分裂等。它對(duì)微管沒有作用, 也不抑制肌收縮, 因肌纖維中肌動(dòng)蛋白絲是穩(wěn)定的結(jié)構(gòu), 不發(fā)生組裝及解聚的動(dòng)態(tài)平衡

常見問(wèn)題列表

簡(jiǎn)介

細(xì)胞松弛素B在細(xì)胞內(nèi)同微絲的正端結(jié)合, 并引起F-肌動(dòng)蛋白解聚,阻斷亞基的進(jìn)一步聚合。當(dāng)將細(xì)胞松弛素加入到活細(xì)胞后,肌動(dòng)蛋白纖維骨架消失,使動(dòng)物細(xì)胞的各種活動(dòng)癱瘓, 包括細(xì)胞的移動(dòng)、吞噬作用、胞質(zhì)分裂等。

14930-96-2

生物活性
Cytochalasin B 是一種能透過(guò)細(xì)胞的真菌毒素,能夠與肌動(dòng)蛋白絲的有刺端結(jié)合,擾亂肌動(dòng)蛋白聚合物的形成,對(duì) F-actin 的 Kd 值為 1.4-2.2 nM。
靶點(diǎn)

Kd: 2.2 nM (F-actin, with Mg 2+ ), 1.4 nM (F-actin, with Mg 2+ /K + )

體外研究

Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, inhibits the enlongation and shortening of actin filaments, with K d s of 2.2 nM and 1.4 nM for F-actin in the presence of MgCl 2 (2 mM) or MgCl 2 (2 mM) plus KCl, respectively. Cytochalasin B (0.1-10 μM) shows inhibitory effect on multiple murine cancer cell lines, with IC 50 s of 2.56 μM (M109c), 10.46 μM (B16BL6), 105.5 μM (P388/ADR), 51.9 μM (P388/S) and IC 80 s of 12.23 μM (M109c), 44.86 μM (B16BL6), 188.4 μM (P388/ADR), 84.1 μM (P388/S) after treatment for 3 h, with IC 50 s of 0.25 μM (M109c), 0.37 μM (B16F10), 0.87 μM (B16BL6), and IC 80 s of 0.75 μM (M109c), 1.21 μM (B16F10), 10.41 μM (B16BL6) after treatment for 4 days. Cytochalasin B (6 μM) increases the myofibrillar fragmentation index (MFI), which is attributed to the intensely breaking of myofibrillar proteins into short segments. Cytochalasin B also accelerates the disruption of actin filaments. In addition, Cytochalasin B accelerates the transformation from F-actin to G-actin, lowering the content of F-actin and significantly increasing G-actin bands during postmortem conditioning.

體內(nèi)研究

Cytochalasin B (10, 25, 50 mg/kg, i.p.) dose-dependently increases the life expectancy of Balb/c mice bearing with P388/ADR leukemias. Cytochalasin B at 50 mg/kg produces 10 % long-term survival in the multidrug resistant P388/ADR cohort, and 40 % long-term survival in the drug sensitive P388/S cohort.

細(xì)胞松弛素 B價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/11XW149309624細(xì)胞松弛素B
cytochalasin b from drechslera dematioidea;phomin
14930-96-21MG791元
2024/11/0822809細(xì)胞松弛素B
Cytochalasin B
14930-96-21mg1235元
2024/11/0822809細(xì)胞松弛素B
Cytochalasin B
14930-96-25mg3939元
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