149022-22-0
149022-22-0 結(jié)構(gòu)式
基本信息
阿米卡霉素硫酸
硫酸阿米卡星(5:9)
阿米卡星硫酸鹽(5:9)
磺胺甲惡唑149022-22-0
硫酸阿米卡星149022-22-0
O-3-氨基-3-脫氧-Α-D-吡喃葡萄糖基-(1→6)-O-[6-氨基-6-脫氧-Α-D-吡喃葡萄糖基-(1→4)]-N1-[(2S)-4-氨基-2-羥基-1-氧丁基]-2-脫氧-D-鏈胺硫酸鹽(5:9)
AMIKASIN SULFATE
Amikacin sulfate(5:9)
Amikacin sulfate salt
AMIKACIN SULFATE 1:1.8
mikacin disulfate salt
Amikacin sulfate salt USP/EP/BP
AMIKACIN SULFATE SALT, AMINOGLYCOSID
O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine sulfate(5:9)
(2S)-4-AMino-N-{(1R,2S,3S,4R,5S)-5-aMino-2-[(3-aMino-3-deoxy-a-D-glucopyranosyl)oxy]-4-[(6-aMino-6-deoxy-a-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanaMide sulfate (1:2)
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by
Nocardia asteroides
,
Mycobacterium avium-intracellulare
, and certain species of "rapid-growing" mycobacteria (that is,
M. chelonae
and
M. fortuitumi
).
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD
50
value of 453 μM.
Amikacin (320?mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.
| Animal Model: | Male Fischer 344 rats (40-50-day-old) |
| Dosage: | 320?mg/kg |
| Administration: | Subcutaneous injection; daily; for 10 days |
| Result: | Induced hearing loss in rats. |