148470-19-3
中文名稱
SUBSTANCE P TFA
英文名稱
Substance P TFA
CAS
148470-19-3
分子式
C65H99F3N18O15S
分子量
1461.67
MOL 文件
148470-19-3.mol
148470-19-3 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度Water: 1 mg/ml
形態(tài)A lyophilized powder
顏色White to off-white
水溶解性Water: 100 mg/mL
SUBSTANCE P TFA價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-P0201A | SUBSTANCE P TFA Substance P TFA | 148470-19-3 | 1mg | 500元 |
| 2024/11/08 | HY-P0201A | SUBSTANCE P TFA Substance P TFA | 148470-19-3 | 5mg | 1100元 |
| 2024/11/08 | HY-P0201A | SUBSTANCE P TFA Substance P TFA | 148470-19-3 | 10mg | 2000元 |
常見問題列表
生物活性
Substance P TFA (Neurokinin P TFA) 是一種神經(jīng)肽，在中樞神經(jīng)系統(tǒng)中作為神經(jīng)遞質(zhì)和神經(jīng)調(diào)節(jié)劑。Substance P 的內(nèi)源性受體是神經(jīng)激肽1受體 (neurokinin 1 receptor，NK1R)。靶點(diǎn)
Neurokinin 1 receptor
體外研究
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.