MMP

Ro 31-9790 inhibits L-selectin shedding from mouse and human lymphocytes, Jurkat T cells, and human monocytes with an IC ₅₀ of 0.3-0.4 μM on these cell types. The IC ₅₀ values obtained for Ro 31-9790 are 4.82?±?0.75 μM, 1.16?±?0.27 μM, 0.70?±?0.06 μM, 4.47±?1.27 μM and 0.38?±?0.05 μM for mouse lymphocyte L-selectin shedding, Jurkat L-selectin shedding, human lymphocyte L-selectin shedding, human monocyte L-selectin shedding and human monocyte TNF-α shedding.