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1445605-23-1

中文名稱 (1S,2R)-N1-(3,4-二氯苯基)環(huán)己烷-1,2-二甲酰胺
英文名稱 Lu AF21934
CAS 1445605-23-1
分子式 C14H16Cl2N2O2
分子量 315.2
MOL 文件 1445605-23-1.mol
更新日期 2024/11/08 11:24:22
1445605-23-1 結(jié)構(gòu)式 1445605-23-1 結(jié)構(gòu)式

基本信息

中文別名
化合物L(fēng)U AF21934
(1S,2R)-N1-(3,4-二氯苯基)環(huán)己烷-1,2-二酰胺
英文別名
CS-2215
Lu AF21934
LuAF21934, >98%
LU-AF 21934
LU AF 21934
LU AF-21934
LU AF 21934
LU-AF21934
LU-AF-21934
(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide
1,2-Cyclohexanedicarboxamide, N1-(3,4-dichlorophenyl)-, (1S,2R)-
2-PYRIMIDINAMINE,4-METHYL-N-[5-METHYL-4-(1H-PYRAZOL-4-YL)-2-THIAZOLYL]-, >98%
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

沸點577.6±50.0 °C(Predicted)
密度1.386±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度≥31.5 mg/mL in DMSO; insoluble in H2O; ≥5.03 mg/mL in EtOH with ultrasonic
酸度系數(shù)(pKa)13.23±0.70(Predicted)
形態(tài)固體
顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319
(1S,2R)-N1-(3,4-二氯苯基)環(huán)己烷-1,2-二甲酰胺價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-100366(1S,2R)-N1-(3,4-二氯苯基)環(huán)己烷-1,2-二甲酰胺
Lu AF21934
1445605-23-15mg850元
2024/11/08HY-100366(1S,2R)-N1-(3,4-二氯苯基)環(huán)己烷-1,2-二甲酰胺
Lu AF21934
1445605-23-110mM * 1mLin DMSO935元
2024/11/08HY-100366(1S,2R)-N1-(3,4-二氯苯基)環(huán)己烷-1,2-二甲酰胺
Lu AF21934
1445605-23-110mg1450元

常見問題列表

生物活性
Lu AF21934 是選擇性和腦滲透性的 mGlu4 受體正變構(gòu)調(diào)節(jié)劑,對 mGlu4 受體的 EC50 為 500。
靶點

mGlu4 Receptor

500 nM (EC 50 )

體內(nèi)研究

Lu AF21934 treatment shows a dose-dependent anxiolytic-like effect in the stress-induced hyperthermia, four-plate, and marble-burying tests. The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test is inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and is not serotonin dependent. Lu AF21934 does not produce antidepressant-like effects in the tail suspension test in mice; however, it decreases the basal locomotor activity of mice that are not habituated to activity cages. Lu AF21934 (0.5-5 mg/kg sc) does not influence tremor but at doses of 0.5 and 2.5 mg/kg reverses harmaline-induced hyperactivity. Lu AF21934 at a dose of 2.5 mg/kg potentiates the inhibitory influence of harmaline on the exploratory activity and AP1 during the first 30 min of the measurement and counteracts the harmaline-increased basic activity during the period of 30-90 min. Lu AF21934 (0.1-5 mg/kg) dose-dependently inhibits hyperactivity induced by MK-801 or amphetamine. It also antagonizes head twitches and increases frequency of spontaneous excitatory postsynaptic currents in brain slices, induced by DOI.

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