143584-75-2
中文名稱
143584-75-2
英文名稱
S-methyl-KE-298
CAS
143584-75-2
更新日期
2024/11/05 13:11:14
分子式
C13H16O3S
分子量
252.33
MOL 文件
143584-75-2.mol
143584-75-2 結(jié)構(gòu)式
物理化學性質(zhì)
沸點457.2±45.0 °C(Predicted)
密度1.188±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.11±0.23(Predicted)
形態(tài)Solid
顏色White to off-white
143584-75-2價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2021/03/30 | S0300 | 143584-75-2 S-methyl-KE-298 | 143584-75-2 | 5mg | 3988.53元 |
| 2021/03/30 | S0300 | 143584-75-2 S-methyl-KE-298 | 143584-75-2 | 25mg | 12031.1元 |
常見問題列表
生物活性
S-methyl-KE-298 是 KE-298 的一種活性代謝物。KE-298 抑制類風濕關(guān)節(jié)炎 (RA) 滑膜細胞的基質(zhì)金屬蛋白酶 (MMP-1) 產(chǎn)生。體外研究
S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production from rheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells.