143413-47-2
基本信息
(ARG)9游離態(tài)
POLY ARGININE 9
RRRRRRRRR
Peptide R9
R 9 peptide
Nonaarginine
(Arg)9 peptide
H-RRRRRRRRR-NH2
Poly Arginine 9
Nona-L-arginine
H(-Arg)9-OH, Nonaarginine
物理化學(xué)性質(zhì)
常見問題列表
IC50: 0.78 μM (neuroprotection)
Poly-arginine (e.g. (Arg)9) and arginine-rich peptides (e.g. TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. (Arg)9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC 50 =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC 50 =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC 50 =6 μM).
(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume.