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143413-47-2

中文名稱 九聚精氨酸
英文名稱 H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
CAS 143413-47-2
分子式 C54H110N36O10
分子量 1423.69
MOL 文件 143413-47-2.mol
更新日期 2024/11/01 22:01:44
143413-47-2 結(jié)構(gòu)式 143413-47-2 結(jié)構(gòu)式

基本信息

中文別名
九聚精氨酸
(ARG)9游離態(tài)
POLY ARGININE 9
英文別名
(ARG)9
RRRRRRRRR
Peptide R9
R 9 peptide
Nonaarginine
(Arg)9 peptide
H-RRRRRRRRR-NH2
Poly Arginine 9
Nona-L-arginine
H(-Arg)9-OH, Nonaarginine
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

密度1.60±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
序列H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH

常見問題列表

生物活性
(Arg)9 (Nona-L-arginine;Peptide R9)是可滲透細(xì)胞的多肽,在谷氨酸模型實(shí)驗(yàn)?zāi)P椭斜Wo(hù)神經(jīng)的IC50值為0.78 μM。
靶點(diǎn)

IC50: 0.78 μM (neuroprotection)

體外研究

Poly-arginine (e.g. (Arg)9) and arginine-rich peptides (e.g. TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. (Arg)9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC 50 =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC 50 =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC 50 =6 μM).

體內(nèi)研究

(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume.

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