1432500-66-7
中文名稱(chēng)
ML334
英文名稱(chēng)
ML334
CAS
1432500-66-7
分子式
C26H26N2O5
分子量
446.49
MOL 文件
1432500-66-7.mol
1432500-66-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12078 英文別名
ML334LH601A
(1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid
(1S,2R)-2-[(1S)-1-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-carbonyl]cyclohexane-1-carboxylic acid
Cyclohexanecarboxylic acid, 2-[[(1S)-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]-, (1S,2R)-
物理化學(xué)性質(zhì)
沸點(diǎn)693.1±55.0 °C(Predicted)
密度1.354±0.06 g/cm3(Predicted)
儲(chǔ)存條件Store at 4°C, stored under nitrogen
溶解度DMSO: 40 mg/ml
酸度系數(shù)(pKa)4.69±0.44(Predicted)
形態(tài)固體
顏色White to off-white
ML334價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-110258 | ML334 ML334 | 1432500-66-7 | 1mg | 681元 |
| 2024/11/08 | HY-110258 | ML334 ML334 | 1432500-66-7 | 5mg | 1500元 |
| 2024/11/08 | HY-110258 | ML334 ML334 | 1432500-66-7 | 10mM * 1mLin DMSO | 1650元 |
常見(jiàn)問(wèn)題列表
生物活性
ML334 (LH601A) 是一種有效的，細(xì)胞可滲透的 NRF2 激活劑，通過(guò)抑制 Keap1-NRF2 蛋白質(zhì)相互作用來(lái)發(fā)揮作用。ML334 以 Kd 值為 1μM 來(lái)結(jié)合 Keap1 Kelch 域。ML334 刺激 NRF2 表達(dá)和核易位并誘導(dǎo)抗氧化反應(yīng)元件 (ARE) 活性。靶點(diǎn)
Ki: 1 μM (Keap1)
體外研究
ML334 (LH601A; 50-100 μM; 6-16 hours; HEK293 cells) treatment increases NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. And also enhances HO-1 mRNA expression between 4- and 7-fold at 6 h, with lesser fold-changes at 16 h.
ML334 (LH601A; 50-100 μM; 16 hours; HEK293 cells) treatment induces HO-1 and TRX1 proteins in HEK293 cells.
ML334 (LH601A) stimulates NRF2 expression and nuclear translocation in HEK293 cells.
RT-PCR
| Cell Line: | HEK293 cells |
| Concentration: | 50 μM or 100 μM |
| Incubation Time: | 6 hours, 16 hours |
| Result: | Increased NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. Enhanced HO-1 mRNA expression between 4- and 7-fold at 6 h. |
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 50 μM or 100 μM |
| Incubation Time: | 16 hours |
| Result: | Enhanced HO-1 and TRX1 protein expression at 16 h. |