142523-38-4
中文名稱
L-690,330
英文名稱
L-690,330
CAS
142523-38-4
分子式
C8H12O8P2
分子量
298.12
MOL 文件
142523-38-4.mol
更新日期
2023/03/20 15:41:19
142523-38-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15685 英文別名
L-690,330[1-(4-HYDROXYPHENOXY)ETHYLIDENE]BISPHOSPHONIC ACID
Phosphonic acid, P,P'-[1-(4-hydroxyphenoxy)ethylidene]bis-
物理化學(xué)性質(zhì)
沸點(diǎn)696.9±65.0 °C(Predicted)
密度1.787±0.06 g/cm3(Predicted)
儲(chǔ)存條件Store at RT
溶解度Water:19.65(Max Conc. mg/mL);65.9(Max Conc. mM)
酸度系數(shù)(pKa)1.44±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
水溶解性Soluble to 20 mM in water
常見(jiàn)問(wèn)題列表
生物活性
L-690330 是一種競(jìng)爭(zhēng)性的肌醇單磷酸酶 (inositol monophosphatase (IMPase)) 抑制劑，對(duì)重組人和牛 IMPase 的 Ki 值為 0.27 μM 和 0.19 μM，對(duì)人和牛前腦皮層 IMPase 的為 Ki 值為 0.30 μM 和 0.42 μM。L-690330 對(duì)其敏感性是大鼠和小鼠的 IMPase 的 10 倍。靶點(diǎn)
Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)
體外研究
L-690330 (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells.
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 50 μM |
| Incubation Time: | 1 hour |
| Result: | Improved LC3-I/II and p-AMPK protein level. |
體內(nèi)研究
L-690330 (intracerebroventricular?injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test.
| Animal Model: | Eight-week-old male ICR mice |
| Dosage: | 0.1 μmol |
| Administration: | Intracerebroventricular?injection |
| Result: | Did not effect mice well-being by i.c.v injection. |