142439-95-0
中文名稱
Sp-Cyclic AMPS (sodium salt)
英文名稱
Sp-Cyclic AMPS (sodium salt)
CAS
142439-95-0
分子式
C10H11N5NaO5PS
分子量
367.253
MOL 文件
142439-95-0.mol
142439-95-0 結(jié)構(gòu)式
常見問題列表
生物活性
Sp-cAMPS sodium salt，一種 cAMP 類似物，是一種依賴 cAMP 的 PKA I 和 PKA II 的有效激活劑。Sp-cAMPS sodium salt 還是一種有效的競(jìng)爭(zhēng)性磷酸二酯酶 (PDE3A) 抑制劑，Ki 為 47.6 μM。Sp-cAMPS sodium salt 以 EC50 為 40 μM 來結(jié)合 PDE10 GAF 域。靶點(diǎn)
|
PKA I
|
PKA II
|
PDE3A 47.6 μM (Ki) |
PDE10 GAF domain 50 μM (EC 50 ) |
體外研究
Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS.
體內(nèi)研究
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 μg/μL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.