1420844-62-7
中文名稱
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
英文名稱
2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-
CAS
1420844-62-7
分子式
C12H18FN3O
分子量
239.29
MOL 文件
1420844-62-7.mol
1420844-62-7 結(jié)構(gòu)式
基本信息
中文別名
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 英文別名
Melanin probe-1N-(2-(Diethylamino)ethyl)-5-fluoropicolinamide
2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-
物理化學(xué)性質(zhì)
沸點(diǎn)370.3±37.0 °C(Predicted)
密度1.102±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 250 mg/mL (1044.76 mM)
酸度系數(shù)(pKa)13.30±0.46(Predicted)
形態(tài)Oil
顏色Light yellow to yellow
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 Melanin probe-1 | 1420844-62-7 | 5mg | 1500元 |
| 2024/11/08 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 Melanin probe-1 | 1420844-62-7 | 10mM * 1mLin DMSO | 1650元 |
| 2024/11/08 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 Melanin probe-1 | 1420844-62-7 | 10mg | 2200元 |
常見(jiàn)問(wèn)題列表
生物活性
Melanin probe-1 是一種基于 18 F-吡啶酰胺的 PET 探針。Melanin probe-1 可用于惡性黑色素瘤的 PET 顯像。Melanin probe-1 具有較高的腫瘤靶向性、良好的腫瘤影像學(xué)對(duì)比，理想的生物分布模式和體內(nèi)穩(wěn)定性好。體內(nèi)研究
Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency.
Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection.
| Animal Model: | C57BL/6 mice bearing B16F10 murine melanomas |
| Dosage: | 3.7 MBq (100 μCi) |
| Administration: | Tail vein |
| Result: | The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively. |