1417997-93-3
中文名稱
MDK-7933
英文名稱
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
CAS
1417997-93-3
分子式
C22H19NO3
分子量
345.39
MOL 文件
1417997-93-3.mol
更新日期
2024/12/16 15:20:14
1417997-93-3 結(jié)構(gòu)式
基本信息
中文別名
化合物HDAC8-IN-1(E)-N-羥基-3-(5-甲氧基-[1,1':4',1''-三聯(lián)苯]-2-基)丙烯酰胺
英文別名
CS-2693MDK-7933
HDAC8-IN-1
HDAC8-IN-22d
HDAC8 inhibitor 1
HDAC8 inhibitor 22d
HDAC8-IN-1 ,MDK7933
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
2-Propenamide, N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-, (2E)-
物理化學(xué)性質(zhì)
密度1?+-.0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度可溶于DMSO
酸度系數(shù)(pKa)8.76±0.23(Predicted)
形態(tài)固體
顏色White to off-white
常見問題列表
生物活性
HDAC8-IN-1 是一個(gè) HDAC8 抑制劑，其 IC50 值為 27.2 nM。靶點(diǎn)
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HDAC8 27.2 nM (IC 50 ) |
體外研究
HDAC8-IN-1 is a HDAC8 inhibitor with an IC 50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells.