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141335-10-6

中文名稱 141335-10-6
英文名稱 LCB-2853
CAS 141335-10-6
分子式 C21H24ClNO4S
分子量 421.94
MOL 文件 141335-10-6.mol
141335-10-6 結(jié)構(gòu)式 141335-10-6 結(jié)構(gòu)式

基本信息

中文別名
化合物 T11825
英文別名
Benzeneacetic acid, 4-[[1-[[[(4-chlorophenyl)sulfonyl]amino]methyl]cyclopentyl]methyl]-

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度溶于二甲基亞砜

常見問題列表

生物活性
LCB-2853 是 thromboxane A2 受體的拮抗劑,具有抗血小板和抗血栓的作用。
靶點(diǎn)

TXA 2 Receptor

體內(nèi)研究

In dog coronary stenosis, LCB 2853 shows a very high efficacy with ED 50 of 7.2 μg/kg. In rat venous thrombosis induced by combination of venous injury and blood stasis, perfused LCB 2853 decreases the weight of thrombi in a dose related manner with ED 50 of 220 μg/kg/min. In vivo, both against platelet aggregation and vasoconstriction, LCB 2853 shows an ED 50 lower than 1 mg/kg i.v. in rat AA-induced thrombocytopenia or U 46619-induced hypertension (ED 50 = 0.25 and 0.16 mg/kg) as well as in AA-induced sudden death in the mouse (ED 50 = 0.44 mg/kg). The U 46619-induced bronchoconstriction is blocked after i.v. administration of LCB 2853 (ED 50 = 18.4 μg/kg).

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