139225-22-2
中文名稱(chēng)
化合物 PANAMESINE
英文名稱(chēng)
(5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one
CAS
139225-22-2
分子式
C23H26N2O6
分子量
426.46
MOL 文件
139225-22-2.mol
139225-22-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 PANAMESINE 英文別名
(5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one2-Oxazolidinone, 5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxy-1-piperidinyl]methyl]-3-(4-methoxyphenyl)-, (5S)-
物理化學(xué)性質(zhì)
熔點(diǎn)165 °C(Solv: ethanol (64-17-5); dichloromethane (75-09-2))
沸點(diǎn)614.1±55.0 °C(Predicted)
密度1.343±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 125 mg/mL (293.11 mM)
酸度系數(shù)(pKa)13.84±0.20(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
常見(jiàn)問(wèn)題列表
生物活性
Panamesine (EMD 57445) 是一種高親和力的 sigma 受體配體，IC50 為 6 nM，有潛力用于非典型抗精神病的研究。靶點(diǎn)
IC50: 6 nM (sigma receptor)
體內(nèi)研究
Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex.
| Animal Model: | Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g |
| Dosage: | 0.3, 1, 3, 30 mg/kg |
| Administration: | Subcutanous injections |
| Result: | Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex. |