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138579-66-5

中文名稱 多克隆抗體
英文名稱 GALANTIDE
CAS 138579-66-5
分子式 C104H151N25O26S
分子量 2199.53
MOL 文件 138579-66-5.mol
更新日期 2024/11/05 13:48:14
138579-66-5 結(jié)構(gòu)式 138579-66-5 結(jié)構(gòu)式

基本信息

中文別名
多克隆抗體
GALANTIDE肽
兔抗PKA R2/PKA II&ICIRC
英文別名
M15
GALANTIDE
M 15 (peptide)
Galantide, M15
GalantideGalanti
GALANTIDE| Galantide
Galantide, ≥90% (HPLC)
GWTLNSAGYLLGPQQFFGLM-NH2
Galanin(1-13)-substance P(5-11)
Rabbit Anti-PKA R2/PKA IIÎ

物理化學(xué)性質(zhì)

沸點(diǎn)2345.4±65.0 °C(Predicted)
密度1.305±0.06 g/cm3(Predicted)
儲存條件−20°C
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.82±0.15(Predicted)
形態(tài)固體
顏色White to off-white

安全數(shù)據(jù)

WGK Germany3
多克隆抗體價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/01/25HY-P0262多克隆抗體
Galantide
138579-66-5500μg1400元
2024/01/25HY-P0262多克隆抗體
Galantide
138579-66-51mg2400元
2024/01/25HY-P0262多克隆抗體
Galantide
138579-66-55mg7200元

常見問題列表

生物活性
Galantide 是一種特殊的甘丙肽受體 (galanin receptor) 拮抗劑,是一種由甘丙肽和 P 物質(zhì)片段組成的肽段,在大鼠下丘腦可識別兩類甘丙肽結(jié)合位點(diǎn) (KD 分別小于 0.1 nM 和 ~6 nM)。Galantide 劑量依賴性 (IC50=1.0 nM) 拮抗甘丙肽介導(dǎo)的葡萄糖誘導(dǎo)的小鼠胰島胰島素分泌抑制。Galantide 似乎與單一的 SP 受體群結(jié)合 (KD~40 nM)。
體外研究

Galantide do not activate the K + conductance but produces a concentration-dependent antagonism (IC 50 =4 nM) of the galanin-induced increase in K + conductance. Galantide acts like galanin and inhibits the voltage-dependent Ba2+ current (IBa). The inhibition of IBa also is concentration dependent (IC 50 =16 nM) and the maximum inhibition produced by galantide is approximately 40%.

體內(nèi)研究

Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM.

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