1385035-79-9
中文名稱(chēng)
GNA002
英文名稱(chēng)
GNA002
CAS
1385035-79-9
分子式
C42H55NO8
分子量
701.9
MOL 文件
1385035-79-9.mol
1385035-79-9 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)864.7±65.0 °C(Predicted)
密度1.22±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)7.10±0.60(Predicted)
形態(tài)Oil
顏色Light yellow to yellow
應(yīng)用領(lǐng)域
用途一
GNA002 is a highly potent, specific and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor. It can specifically and covalently bind to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination.