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138398-61-5

中文名稱(chēng) AMYLIN (8-37) (RAT)
英文名稱(chēng) AMYLIN (8-37) (RAT)
CAS 138398-61-5
分子式 C140H227N43O43
分子量 3200.61
MOL 文件 138398-61-5.mol
更新日期 2024/12/16 10:25:33
138398-61-5 結(jié)構(gòu)式 138398-61-5 結(jié)構(gòu)式

基本信息

中文別名
天然胰淀素(淀粉樣肽)8-37,鼠
英文別名
AMYLIN (8-37) (RAT)
Amylin (8-37) (mouse, rat)
AMYLIN (8-37) (RAT) USP/EP/BP
ATQRLANFLVRSSNNLGPVLPPTNVGSNTY-NH2
diabetes associated peptide amide*fragment 8-37 R
Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2
H-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-ARG-SER-SER-ASN-ASN-LEU-GLY-PRO-VAL-LEU-PRO-PRO-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2
Amylin (8-37) (mouse, rat) H-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2
LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-ARG-SER-SER-ASN-ASN-LEU-GLY-PRO-VAL-LEU-PRO-PRO-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2: KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTY-NH2DISULFIDE BRIDGE CYS2-CYS7
L-Tyrosinamide, L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-arginyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-leucylglycyl-L-prolyl-L-valyl-L-leucyl-L-prolyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-t...
所屬類(lèi)別
生物化工:多肽

物理化學(xué)性質(zhì)

密度1.51±0.1 g/cm3(Predicted)
儲(chǔ)存條件-15°C
形態(tài)Solid
顏色White to off-white
AMYLIN (8-37) (RAT)價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-P1473AMYLIN (8-37) (RAT)
Amylin (8-37), rat
138398-61-5500μg1600元
2024/11/08HY-P1473AMYLIN (8-37) (RAT)
Amylin (8-37), rat
138398-61-51mg2600元
2024/08/19HY-P1473AMYLIN (8-37) (RAT)
Amylin (8-37), rat
138398-61-55mg6500元

常見(jiàn)問(wèn)題列表

生物活性
Amylin (8-37), rat 是天然胰淀素的一種截短肽段,其選擇性抑制肌肉組織中胰島素相關(guān)的葡萄糖攝取和糖原沉積。Amylin (8-37), rat 是一種稍弱的胰淀素受體 (amylin receptor, AMY) 拮抗劑。
靶點(diǎn)

Amylin receptor (AMY)

體外研究

Amylin (8-37), rat (Rat amylin-(8-37)) enhances insulin action and alters lipid metabolism in normal and insulin-resistant rats. Amylin (8-37) reduces plasma insulin (P<0.001) and enhances several measures of whole body and muscle insulin sensitivity (P<0.05) in both saline- and hGH-infused rats. Amylin-(8-37) corrects hGH-induced liver insulin resistance, increases basal plasma triglycerides and lowers plasma nonesterified fatty acids in both groups, and reduces muscle triglyceride and total long-chain acyl-CoA content in saline-treated rats (P<0.05). In isolated soleus muscle, Amylin (8-37) blocks amylin-induced inhibition of glycogen synthesis but has no effect in the absence of amylin. Thus 1) hyperamylinemia accompanies insulin resistance induced by hGH infusion; 2) Amylin (8-37) increases whole body and muscle insulin sensitivity and consistently reduces basal insulin levels in normal and hGH-induced insulin resistant rats; and 3) Amylin (8-37) elicits a significant alteration of in vivo lipid metabolism.

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