1374516-07-0
中文名稱
TUG 891
英文名稱
TUG 891
CAS
1374516-07-0
分子式
C23H21FO3
分子量
364.41
MOL 文件
1374516-07-0.mol
更新日期
2024/11/06 17:53:37
1374516-07-0 結(jié)構(gòu)式
基本信息
中文別名
化合物TUG8913-(4-((4-氟-4'-甲基-[1,1'-聯(lián)苯]-2-基)甲氧基)苯基)丙酸
英文別名
CS-2448TUG 891
TUG 891
TUG-891
4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid
Benzenepropanoic acid, 4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)540.8±50.0 °C(Predicted)
密度1.199±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度DMSO:30.0(Max Conc. mg/mL);82.32(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.72(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.74(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.72(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.74(Max Conc. mM)
酸度系數(shù)(pKa)4.70±0.10(Predicted)
形態(tài)粉末
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
TUG-891是一種有效的、選擇性 long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120) 激動(dòng)劑。靶點(diǎn)
| Target | Value |
|
FFA4/GPR120
() |
體外研究
TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca 2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor.