137338-43-3
中文名稱(chēng)
137338-43-3
英文名稱(chēng)
LAS 31180
CAS
137338-43-3
分子式
C11H12N2O3S
分子量
252.29
MOL 文件
137338-43-3.mol
137338-43-3 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)386.7±52.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)5.70±0.20(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
LAS-31180 是一種 phosphodiesterase 3 的抑制劑，能夠增強(qiáng)肌肉收縮和血管舒張。體外研究
LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC 50 of 1.2 mumol/L) and in isolated guinea-pig working hearts.
體內(nèi)研究
In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure.