1370046-40-4
中文名稱
1370046-40-4
英文名稱
SSE15206
CAS
1370046-40-4
分子式
C19H21N3O3S
分子量
371.45
MOL 文件
1370046-40-4.mol
更新日期
2023/03/20 15:41:27
1370046-40-4 結(jié)構(gòu)式
基本信息
中文別名
SSE15206游離化合物SSE15206
3-苯基-5-(3,4,5-三甲氧基苯基)-4,5-二氫-1H-吡唑-1-硫代酰胺
英文別名
SSE15206SSE-15206
SSE 15206
SSE15206
SSE-15206
SSE 15206
1370046-40-4
3-Phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide
1H-Pyrazole-1-carbothioamide, 4,5-dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-
物理化學(xué)性質(zhì)
沸點(diǎn)518.7±60.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO:112.0(Max Conc. mg/mL);301.52(Max Conc. mM)
酸度系數(shù)(pKa)14.12±0.60(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
1370046-40-4價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-111425 | 1370046-40-4 SSE15206 | 1370046-40-4 | 5mg | 400元 |
| 2024/11/08 | HY-111425 | 1370046-40-4 SSE15206 | 1370046-40-4 | 10mg | 600元 |
| 2024/11/08 | HY-111425 | 1370046-40-4 SSE15206 | 1370046-40-4 | 25mg | 1100元 |
常見(jiàn)問(wèn)題列表
生物活性
SSE15206 是一種微管 (microtubule) 聚合抑制劑，其在 HCT116 細(xì)胞中的 GI50 值為 197 nM，能克服多重耐藥性。引起細(xì)胞中紡錘體形成不完全，從而導(dǎo)致 G2/M 阻滯，有絲分裂異常。靶點(diǎn)
GI50: 197 nM (microtubule).
體外研究
SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI 50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines.
Western Blot Analysis
| Cell Line: | Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells. |
| Concentration: | 5 × and 10 × GI 50 values (GI 50 =197 nM in HCT-116 cells). |
| Incubation Time: | 24 hours. |
| Result: | Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells. |