1357349-91-7
中文名稱
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
英文名稱
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS
1357349-91-7
分子式
C16H15N5
分子量
277.32
MOL 文件
1357349-91-7.mol
更新日期
2024/10/25 11:12:40
1357349-91-7 結(jié)構(gòu)式
基本信息
中文別名
化合物SPP-86 英文別名
SPP 86SPP86 >=98% (HPLC)
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-
物理化學(xué)性質(zhì)
沸點(diǎn)495.3±40.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)3.95±0.30(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-110193 | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SPP-86 | 1357349-91-7 | 1mg | 480元 |
| 2024/08/19 | HY-110193 | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SPP-86 | 1357349-91-7 | 5mg | 1200元 |
| 2024/08/19 | HY-110193 | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SPP-86 | 1357349-91-7 | 10mM * 1mLin DMSO | 1320元 |
常見(jiàn)問(wèn)題列表
生物活性
SPP-86 是一種選擇性的 RET 酪氨酸激酶的有效抑制劑，其 IC50 值為 8 nM。SPP-86 抑制 MCF7 細(xì)胞中 RET 誘導(dǎo)激活的 PI3K/Akt 和 MAPK 信號(hào)通路，也能抑制 RET 誘導(dǎo)的 ERα 磷酸化。靶點(diǎn)
IC50: 8 nM (RET).
體外研究
SPP86 (0-10 μM) inhibits MAPK signaling and proliferation in RET/PTC1 expressing TPC1 but not 8505C or C643 cells.
SPP86 (0-10 μM) inhibits RET- induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells.
Western Blot Analysis
| Cell Line: | Thyroid cancer derived cell lines expressing the RET/PTC1 rearrangement (TPC1), BRAF V600E (8505C) or RAS G13R (C643) mutations. |
| Concentration: | 0-10 μM. |
| Incubation Time: | 90 min. |
| Result: | Inhibited RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines. |
Western Blot Analysis
| Cell Line: | MCF7 cells (human breast cancer). |
| Concentration: | 0-10 μM. |
| Incubation Time: | 30 min. |
| Result: | Inhibited RET- induced ERα phosphorylation and proliferation in MCF7 cells. |