133825-81-7
中文名稱(chēng)
NEVANIMIBE HYDROCHLORIDE
英文名稱(chēng)
PD 132301-2
CAS
133825-81-7
更新日期
2023/03/20 15:41:21
分子式
C27H40ClN3O
分子量
458.09
MOL 文件
133825-81-7.mol
133825-81-7 結(jié)構(gòu)式
基本信息
中文別名
化合物NEVANIMIBE HYDROCHLORIDE 英文別名
ATR-101 HClPD 132301-2
Nevanimibe)
ATR-101 (PD-132301
ATR101 hydrochloride
PD-132301 hydrochloride
Nevanimibe hydrochloride
物理化學(xué)性質(zhì)
儲(chǔ)存條件4°C, away from moisture
溶解度DMSO : 41.67 mg/mL (90.97 mM; Need ultrasonic)| (insoluble)
形態(tài)Solid
顏色White to off-white
水溶解性Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
NEVANIMIBE HYDROCHLORIDE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100399A | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride | 133825-81-7 | 5mg | 2900元 |
| 2024/11/08 | HY-100399A | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride | 133825-81-7 | 10mM * 1mLin DMSO | 3190元 |
| 2024/11/08 | HY-100399A | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride | 133825-81-7 | 10mg | 4600元 |
常見(jiàn)問(wèn)題列表
生物活性
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一種口服有效的，選擇性?；o酶 A：膽固醇 O-?；D(zhuǎn)移酶 1 (ACAT1) 抑制劑，EC50 為 9 nM。Nevanimibe hydrochloride 抑制 ACAT2，EC50 為 368 nM。Nevanimibe hydrochloride 誘導(dǎo)細(xì)胞凋亡 (apoptosis)，并具有抗腎上腺皮質(zhì)癌的潛力。靶點(diǎn)
|
ACAT1 9 nM (EC 50 ) |
ACAT2 368 nM (EC 50 ) |
體外研究
Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability.
Cell Cytotoxicity Assay
| Cell Line: | The H295R and HAC clone 15 (HAC15) human ACC cell lines |
| Concentration: | 3 nM-30 μM |
| Incubation Time: | 24 hours |
| Result: | 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours. |