1335282-05-7
1335282-05-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度Methanol: 5mg/mL,Methanol:PBS (pH 7.2) (1:1): 0.5mg/mL
形態(tài)Solid
顏色Off-white to light brown
常見問題列表
生物活性
CN128 hydrochloride (CN328) 是一種有口服活性、選擇性的鐵螯合劑 (iron chelator)。CN128 被用于 β-地中海貧血的研究。體外研究
CN128 hydrochloride possesses a high selectivity for iron(III) over others metals.
體內(nèi)研究
CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat.
The iron removal efficacies of CN128 displays a dose-dependent behavior.
CN128 hydrochloride lacks genetic toxicity.
CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg.
CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats.
| Animal Model: | Male SD rats (300 g) |
| Dosage: | 450 μmol/kg |
| Administration: | Oral gavage, 1 hour after 59 Fe-ferritin injection |
| Result: | Exhibited good iron scavenging activity. |
| Animal Model: | Sprague-Dawley rats (200~250 g) |
| Dosage: | 75 μmol/kg (Pharmacokinetic Analysis) |
| Administration: | Oral administration |
| Result: | AUC values= 16.38 mg/L?h, C max =8.671 mg/L. |