1334177-96-6
中文名稱
吡啶二硫丙酰胺-八聚乙二醇-丙酸
英文名稱
SPDP-PEG8-acid
CAS
1334177-96-6
分子式
C27H46N2O11S2
分子量
638.791
MOL 文件
1334177-96-6.mol
1334177-96-6 結(jié)構(gòu)式
基本信息
中文別名
吡啶二硫丙酰胺-八聚乙二醇-丙酸 英文別名
SDPD-PEG8-COOHSPDP-PEG8-acid
SPDP-PEG8-COOH
Opss-peg(8)-cooh
Propanoic acid, 3-[[25-oxo-27-(2-pyridinyldithio)-3,6,9,12,15,18,21-heptaoxa-24-azaheptacos-1-yl]oxy]-
應(yīng)用領(lǐng)域
用途一
SPDP-PEG8-acid is a PEG linker containing SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic properties of the PEG linkers increase compound solubility in aqueous media.