1314217-69-0
中文名稱
AZD8529 mesylate
英文名稱
AZD8529 mesylate
CAS
1314217-69-0
更新日期
2023/03/20 15:41:25
分子式
C25H28F3N5O6S
分子量
583.58
MOL 文件
1314217-69-0.mol
1314217-69-0 結構式
常見問題列表
生物活性
AZD-8529 mesylate 是一種有效的，高度選擇性的，可口服的 mGluR2 正向調節(jié)劑，EC50 值為 285 nM；在 20-25 M 的濃度范圍內，對 mGluR1，3，4，5，6，7 和 8 沒有正向調節(jié)作用。靶點
|
mGluR2 285 nM (EC 50 ) |
體外研究
AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC
50
of 195 nM .
AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM.
體內研究
AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys.
AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats.
| Animal Model: | Sprague-Dawley rats |
| Dosage: | 10 mg/kg, 30 mg/kg |
| Administration: | Intraperitoneal injection; 2 hours before nicotine injections |
| Result: | Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats. |