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131334-43-5

中文名稱 HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE
英文名稱 H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
CAS 131334-43-5
分子式 C72H104N20O16S
分子量 1537.79
MOL 文件 131334-43-5.mol
更新日期 2024/11/01 22:01:48
131334-43-5 結構式 131334-43-5 結構式

基本信息

中文別名
髓鞘蛋白脂蛋白
髓鞘蛋白脂蛋白H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
英文別名
MYELIN PROTEOLIPID PROTEIN (139-151)
PLP (HUMAN, BOVINE, DOG, MOUSE, RAT)
Myelin Proteolipid Protein (139-151) (1)
6:PN:WO2012154215 SEQID:5 unclaimed protein
HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE
H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
PLP (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)
MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT)
LIPOPHILIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)
MYELIN PROTEOLIPID PROTEIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)

物理化學性質

沸點1897.4±65.0 °C(Predicted)
密度1.332±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)3.49±0.10(Predicted)
形態(tài)白色至類白色粉末。
顏色White to off-white
序列H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH

常見問題列表

生物活性
PLP (139-151) 是髓鞘蛋白脂蛋白 (PLP) 139至151氨基酸片段。用于誘導實驗性自身免疫性腦脊髓炎 (EAE)。
體外研究

Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151).

體內研究

PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease.

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