1311174-68-1
中文名稱(chēng)
1311174-68-1
CAS
1311174-68-1
分子式
C27H33N5O4
分子量
491.58
MOL 文件
1311174-68-1.mol
更新日期
2024/11/04 11:32:28
1311174-68-1 結(jié)構(gòu)式
基本信息
中文別名
4-[[[4-[[2-(3,4-二氫-3-甲基-4-氧代-1-酞嗪基)乙?；鵠氨基]苯基]甲基]-1-哌嗪羧酸叔丁酯 英文別名
PH002PH 002
PH-002
PH-002 >=98% (HPLC)
PH002
PH-002
PH 002
4-[[4-[[2-(3,4-Dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
1-Piperazinecarboxylic acid, 4-[[4-[[2-(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester
物理化學(xué)性質(zhì)
儲(chǔ)存條件Keep in dark place,Sealed in dry,2-8°C
溶解度DMSO：可溶10mg/mL（澄清溶液）
形態(tài)粉末
顏色白色至米色
常見(jiàn)問(wèn)題列表
生物活性
PH-002 是一種抑制載脂蛋白 (apo) E4 神經(jīng)內(nèi)分子相互作用的抑制劑，其 IC50 (FRET) 值為116 nM。靶點(diǎn)
116 nM (Apo E4 in FRET).
體外研究
PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an IC 50 of 116 nM in FRET.
體內(nèi)研究
PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons).