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13095-47-1

中文名稱 R-2-羥基戊二酸
英文名稱 2-hydroxypentanedioic acid
CAS 13095-47-1
分子式 C5H8O5
分子量 148.11
MOL 文件 13095-47-1.mol
13095-47-1 結(jié)構(gòu)式 13095-47-1 結(jié)構(gòu)式

基本信息

中文別名
R-2-羥基戊二酸
英文別名
R-2-HYDROXYGLUTARATE
D-2-hydroxyglutarate
D--Hydroxyglutaric Acid
D-α-Hydroxyglutaric Acid
D-2-Hydroxyglutaric acid
(2R)-hydroxyglutaric acid
(R)-2-Hydroxyglutaric acid
2-hydroxypentanedioic acid
D-alpha-Hydroxyglutaric acid
(R)-alpha-Hydroxyglutaric acid

物理化學(xué)性質(zhì)

沸點(diǎn)394.2±27.0 °C(Predicted)
密度1.508±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C
溶解度DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 30 mg/mL; PBS (pH 7.2): 10 mg/mL
酸度系數(shù)(pKa)3.67±0.10(Predicted)
R-2-羥基戊二酸價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2023/03/20HY-113038R-2-羥基戊二酸
D-α-Hydroxyglutaric acid
13095-47-15mg1800元
2023/03/20HY-113038R-2-羥基戊二酸
D-α-Hydroxyglutaric acid
13095-47-110mg2900元
2023/03/20HY-113038R-2-羥基戊二酸
D-α-Hydroxyglutaric acid
13095-47-125mg4400元

常見問題列表

生物活性
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) 是神經(jīng)代謝疾病 D-2-羥基戊二酸尿癥中積累的主要代謝產(chǎn)物。D-α-Hydroxyglutaric acid 是 α-酮戊二酸 (α-KG) 的弱競爭拮抗劑,可抑制多種 α-KG 依賴性雙加氧酶 (dioxygenases),Ki 為 10.87 mM。D-α-Hydroxyglutaric acid 可增加活性氧 (ROS) 的產(chǎn)生。D-α-Hydroxyglutaric acid 還可結(jié)合并抑制 ATP 合酶并抑制 mTOR 信號(hào)傳導(dǎo)。
靶點(diǎn)

Ki: 10.87 mM (α-KG-dependent dioxygenases)
ATP synthase
mTOR
Reactive oxygen species (ROS)

體外研究

D-α-Hydroxyglutaric acid ((R)-2-hydroxyglutarate) accumulates in human cancers carrying neomorphic mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes.
A partial inhibition of KDM7A toward both H3K9me2 and H3K27me2 peptides is observed in the presence of 50 mM D-2-HG and 100 μM α-ketoglutarate (α-KG). Addition of 300 μM α-KG is capable of reversing the inhibition of Caenorhabditis elegans KDM7A (CeKDM7A) by 50 mM D-2-HG, indicating that D-2-HG is a weak competitive inhibitor against α-KG toward the CeKDM7A demethylase.
D-α-Hydroxyglutaric acid is a weak inhibitor of TET hydroxylases. In the presence of 0.1 mM of α-KG, addition of 10 mM D-α-Hydroxyglutaric acid results in a partial (33%) inhibition of TET2 and addition of 50 mM D-α-Hydroxyglutaric acid results in more inhibition (83%) of TET2. D-α-Hydroxyglutaric acid exhibits a less pronounced inhibitory effect toward TET1.

體內(nèi)研究

D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO 2 production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism.
D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors.
D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats.

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