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130089-98-4

中文名稱 NQ301
英文名稱 NQ301
CAS 130089-98-4
分子式 C18H12ClNO3
分子量 325.75
MOL 文件 130089-98-4.mol
更新日期 2023/03/20 15:41:27
130089-98-4 結(jié)構(gòu)式 130089-98-4 結(jié)構(gòu)式

基本信息

中文別名
化合物NQ301
英文別名
NQ301
NQ 301
NQ-301
NQ301 >=98% (HPLC)
NQ301 - Compound 211
2-(4-Acetylanilino)-3-chloronaphthalene-1,4-dione
2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione
2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro-
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)241-243 °C(Solv: ethanol (64-17-5))
沸點(diǎn)476.8±45.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO:10.0(Max Conc. mg/mL);30.7(Max Conc. mM)
酸度系數(shù)(pKa)-5.25±0.20(Predicted)
形態(tài)粉末
顏色淡紅色至深紅色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
警示詞警告
危險(xiǎn)性描述H315-H319-H335-H400
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
NQ301價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-101054NQ301
NQ301
130089-98-45mg600元
2024/11/08HY-101054NQ301
NQ301
130089-98-410mM * 1mLin DMSO660元
2024/11/08HY-101054NQ301
NQ301
130089-98-410mg900元

常見問題列表

生物活性
NQ301 (Compound 211) 是一種抗血小板和抗血栓形成劑,也是一種選擇性的 CD45 的抑制劑,IC50值為200 nM。NQ301 可抑制兔血小板中的 thromboxane A2 receptor (TXA2) 和合酶synthase的活性。
靶點(diǎn)
TargetValue
TXA2 receptor
()
CD45
(Cell-free assay)
200 nM
體外研究

NQ301 concentration-dependently inhibits collagen (10 mg/mL)-, U46619 (1 mg/mL)- and arachidonic acid (100 mg/mL)-challenged rabbit platelet aggregation, with IC 50 values of 0.60±0.02, 0.58±0.04 and 0.78±0.04 μM, respectively. NQ301 potently suppresses thromboxane B 2 formation by platelets that are exposed to arachidonic acid in a concentration-dependent manner, but had no effect on the production of prostaglandin D 2 , indicating an inhibitory effect on thromboxane A 2 synthase. NQ301 has a potential to inhibit thromboxane A 2 synthase activity with thromboxane A 2 /prostaglandin H 2 receptor blockade, and modulate arachidonic acid liberation as well as 12-hydroxy-5,8,10,14-eicosatetraenoic acid formation in platelets. NQ301 inhibits platelet aggregation by suppression of the intracellular pathway, rather than by direct inhibition of fibrinogen-GPIIb/IIIa complex binding. NQ301 significantly inhibits the increase of cytosolic Ca 2+ concentration and ATP secretion, and also significantly increases platelet cAMP levels in the activated platelets. The antiplatelet activity of NQ301 may be mediated by inhibition of cytosolic Ca 2+ mobilization, enhancement of cAMP production and inhibition of ATP secretion in activated platelets.

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