129424-08-4
129424-08-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15548ICI 211965 (ZM-211965)
英文別名
ZM-211965ICI 211965
2-[1-Methoxy-1-[3-[(2-naphthalenyl)methoxy]phenyl]propyl]thiazole
Thiazole, 2-[1-methoxy-1-[3-(2-naphthalenylmethoxy)phenyl]propyl]-
1-[3-(2-Naphtylmethoxy)phenyl]-1-(2-thiazolyl)propyl(methyl) ether
物理化學(xué)性質(zhì)
沸點(diǎn)544.2±50.0 °C(Predicted)
密度1.190±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)2.77±0.10(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
ICI 211965 (ZM-211965) 是一個(gè)有選擇性且口服有效的 5-脂氧合酶 (5-LPO) 抑制劑。靶點(diǎn)
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5-LPO
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體外研究
ICI 211965 (ZM-211965) is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor. ICI 211965 reduces the leakage of lactate dehydrogenase (LD) and lipid peroxidation at concentrations related to its antioxidative effect and not to its 5-1ipoxygenase-inhibiting effect.