1292285-54-1
中文名稱
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
英文名稱
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
CAS
1292285-54-1
分子式
C14H18N2O3
分子量
262.3
MOL 文件
1292285-54-1.mol
更新日期
2023/03/20 15:41:25
1292285-54-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T16924 英文別名
SPRi 3SPR inhibitor 3
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
Acetamide, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy-
物理化學(xué)性質(zhì)
沸點561.9±50.0 °C(Predicted)
密度1.241±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 100 mM,Ethanol: 100 mM
酸度系數(shù)(pKa)10.14±0.40(Predicted)
形態(tài)固體
顏色Off-white to gray
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-115510 | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide SPR inhibitor 3 | 1292285-54-1 | 5 mg | 1300元 |
| 2024/08/19 | HY-115510 | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide SPR inhibitor 3 | 1292285-54-1 | 10mM * 1mLin DMSO | 1430元 |
| 2024/08/19 | HY-115510 | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide SPR inhibitor 3 | 1292285-54-1 | 10mg | 1850元 |
常見問題列表
生物活性
SPR inhibitor 3 (SPRi3) 是一種有效的 sepiapertin 還原酶 (SPR) 抑制劑。SPR inhibitor 3 (SPRi3) 在非細(xì)胞體系中顯示出與人 SPR 的高結(jié)合親和力 (IC50=74 nM)，在細(xì)胞檢測中有效降低生物喋呤水平 (IC50=5.2 μM)。SPR inhibitor 3 (SPRi3) 通過降低 BH4 水平減少神經(jīng)性和炎癥性疼痛。靶點
IC50: 74 nM (sepiapterin reductase)
體外研究
SPR inhibitor 3 (SPRi3) also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC 50 =0.45 μM) without affecting the activity of GTP cyclohydroxylase 1 enzyme (GCH1).