1260247-42-4
中文名稱(chēng)
LLL12
英文名稱(chēng)
LLL12
CAS
1260247-42-4
分子式
C14H9NO5S
分子量
303.29
MOL 文件
1260247-42-4.mol
1260247-42-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
熔點(diǎn)179-181 °C
沸點(diǎn)618.2±65.0 °C(Predicted)
密度1.626±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)6.46±0.20(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
應(yīng)用領(lǐng)域
用途一
LLL12 is a potent STAT3 inhibitor. LLL12 inhibits colony formation and cell migration and works synergistically with doxorubicin and gemcitabine. LLL12 demonstrated a potent inhibitory activity on breast and glioblastoma tumor growth in a mouse xenograft model. LLL12 may be a potential therapeutic agent for human cancer cells expressing constitutive STAT3 signaling.