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1252679-52-9

中文名稱 1252679-52-9
英文名稱 ITX-5061 HCl
CAS 1252679-52-9
更新日期 2024/06/25 17:15:55
分子式 C30H38ClN3O7S
分子量 620.16
MOL 文件 1252679-52-9.mol
1252679-52-9 結(jié)構(gòu)式 1252679-52-9 結(jié)構(gòu)式

基本信息

中文別名
化合物 T15603
英文別名
ITX-5061
ITX-5061 HCl
ITX-5061 hydrochloride
ITX-5061 hydrochloride (ITX5061)

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 83.3 mg/mL (134.32 mM)
形態(tài)Solid
顏色Light yellow to light brown

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
海關(guān)編碼2933998090

常見問題列表

生物活性
ITX5061 是 一個(gè) II 型 p38 MAPK 抑制劑,也是清道夫受體 B1 (SR-B1) 的拮抗劑。
靶點(diǎn)

p38 MAPK, SR-B1

體內(nèi)研究

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P<0.05), while calculated production rates are identical in both groups (129±24 μg/g/d vs 129±16 μg/g/d). Moreover, accumulation of [ 3 H] CE in the liver is significantly lower in ITX5061-treated mice indicating that increased HDL-CE levels are due to reduced uptake by the liver.

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