124265-89-0
124265-89-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.68±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 230 mg/mL (908.16 mM)
酸度系數(shù)(pKa)9.61±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Omaciclovir (H2G) 是一種有效的選擇性皰疹病毒 herpesvirus 復(fù)制抑制劑。Omaciclovir 是一種核苷類似物。體外研究
Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys.
Omaciclovir shows antiviral activities against different human herpesviruses with EC
50
s of 0.72?±?0.1, 0.62?±?0.2, 0.015?±?0.004, 0.048?±?0.023, 0.047?±?0.004, 0.035?±?0.022, and 0.016?±?0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively.