1217049-32-5
1217049-32-5 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
GYKI-47261 dihydrochloride 是一種競(jìng)爭(zhēng)性、具有口服活性、選擇性 AMPA 受體拮抗劑，IC50為 2.5 μM，具有廣譜抗驚厥和神經(jīng)保護(hù)作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效誘導(dǎo)劑。體內(nèi)研究
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice.
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP.
| Animal Model: | Male C57 black mice, weighing 23-30 g |
| Dosage: | 20 mg/kg |
| Administration: | I.p. |
| Result: | Reversed the MPTP-induced decrease in striatal concentrations. |