120615-25-0
120615-25-0 結(jié)構(gòu)式
基本信息
化合物 CKI-7 FREE BASE
CKI 7 free base,CKI7 free base
N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide
N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide
8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-
8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7
8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-133028 | CKI-7 CKI-7 free base | 120615-25-0 | 5mg | 850元 |
| 2024/11/08 | HY-133028 | CKI-7 CKI-7 free base | 120615-25-0 | 10mg | 1500元 |
| 2024/11/08 | HY-133028 | CKI-7 CKI-7 free base | 120615-25-0 | 10mM * 1mLin DMSO | 1572元 |
常見問題列表
|
CK1 6 μM (IC 50 ) |
CK1 8.5 μM (Ki) |
Cdc7
|
SGK
|
S6K1
|
MSK1
|
CKI-7 (0.1-10 μM; 5 days; ES cells) treatment significantly increases the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner.
CKI-7 (5 μM; 5 days; ES cells) treatment suppresses SFEB-induced β-catenin stabilization on day 5, indicating that CKI-7 inhibits Wnt signaling.
RT-PCR
| Cell Line: | Mouse ES cells |
| Concentration: | 0.1-10 μM |
| Incubation Time: | 5 days |
| Result: | Significantly increased the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner. |
Western Blot Analysis
| Cell Line: | Mouse ES cells |
| Concentration: | 5 μM |
| Incubation Time: | 5 days |
| Result: | Suppressed SFEB-induced β-catenin stabilization on day 5. |
In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death.