1202710-57-3
中文名稱
1202710-57-3
英文名稱
GSTO-IN-2
CAS
1202710-57-3
分子式
C33H52N2O9
分子量
620.77
MOL 文件
1202710-57-3.mol
更新日期
2023/03/20 15:41:27
1202710-57-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T11504 英文別名
GSTO-IN-2GSTO inhibitor 2
L-Aspartic acid, L-γ-glutamyl-, 21-[(3α,5β)-23-carboxy-24-norcholan-3-yl] ester
物理化學(xué)性質(zhì)
沸點821.7±65.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)2.21±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
GSTO-IN-2是一種谷胱甘肽S-轉(zhuǎn)移酶 (glutathione S-transferase) 抑制劑，對于GSTA2，GSTM1和GSTP1-1的 IC50 值分別為3.6，16.3，1.4 μM。靶點
IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)
體外研究
GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231..