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119474-55-4

中文名稱 KB-5246
英文名稱 KB 5246
CAS 119474-55-4
分子式 C18H17ClFN3O4S
分子量 425.86
MOL 文件 119474-55-4.mol
119474-55-4 結(jié)構(gòu)式 119474-55-4 結(jié)構(gòu)式

基本信息

中文別名
化合物 T11744
英文別名
KB 5246

物理化學(xué)性質(zhì)

熔點(diǎn)287 °C (decomp)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜

常見問題列表

生物活性
KB-5246 是一種四環(huán)喹諾酮,具有抗菌活性。
靶點(diǎn)

Bacterial

體外研究

KB-5246 is a tetracyclic quinolone and displays antibacterial activities. The MICs for 90% of isolates tested (MIC90s) of KB-5246 against gram-positive microorganisms such as Staphylococcus aureus , including methicillin-resistant S. aureus , Staphylococcus epidermidis , Streptococcus pneumoniae , and Streptococcus pyogenes , are 0.39 μg/mL. KB5246 inhibits 90% of isolates of Escherichia coli , Klebsiella pneumoniae , Klebsiella oxytoca at a concentration of 0.10 μg/mL or less. When a concentration of KB-5246 at the MIC or higher is added, no regrowth after 24 h of incubation is observed.

體內(nèi)研究

The 50% effective dose values of KB-5246 against S. pneumoniae 2132 infections are 50.5 mg/kg of body weight. The activities of KB-5246 against S. aureus Smith, P. aeruginosa GN11189, and Serratia marcescens GN7577 infections are comparable to those of ofloxacin and greater than those of norfloxacin.

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