1190363-46-2
中文名稱(chēng)
(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮
英文名稱(chēng)
(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one
CAS
1190363-46-2
分子式
C25H33F2NO2Si
分子量
445.62
MOL 文件
1190363-46-2.mol
更新日期
2025/01/13 11:03:25
1190363-46-2 結(jié)構(gòu)式
基本信息
中文別名
BMS-846372雜質(zhì)1(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-氧基-5H-環(huán)庚并[B]吡啶-5-酮
(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[(三異丙基硅)氧基]-5H-環(huán)庚[B]吡啶-5-酮
(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮
(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三(1-甲基乙基)甲硅烷基]氧基]-5H-環(huán)庚并[B]吡啶-5-酮
英文別名
EOS-60325BMS-846372 Impurity 1
5H-Cyclohepta[b]pyridin-5-one, 6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-
ERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE
(6S,9R)-6-(2,3-difluorophenyl)-9-tri(propan-2-yl)silyloxy-6,7,8,9-tetrahydrocyclohepta[b]pyridin-5-one
(6S,9R)-6-(2,3-difluorophenyl)-9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one
(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one
5H-Cyclohepta[b]pyridin-5-one, 6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-, (6S,9R)-
物理化學(xué)性質(zhì)
沸點(diǎn)477.5±45.0 °C(Predicted)
密度1.10±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)2.97±0.60(Predicted)
常見(jiàn)問(wèn)題列表
化學(xué)性質(zhì)
(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮是一種環(huán)庚酮并吡啶有機(jī)化合物，其結(jié)構(gòu)中有一個(gè)被硅基單元保護(hù)的活性羥基反應(yīng)，可在酸性條件下進(jìn)行水解反應(yīng)將硅基保護(hù)基脫除。此外，其結(jié)構(gòu)中含有一個(gè)羰基α碳原子手性中心，它對(duì)堿性物質(zhì)較為敏感，容易在堿的作用下發(fā)生烯醇式互變異構(gòu)導(dǎo)致其手性消失。用途
(6S,9R)-6-(2,3-二氟苯基)-6,7,8,9-四氫-9-[[三異丙基硅烷基]氧基]-5H-環(huán)庚三烯并[B]吡啶-5-酮是一種醫(yī)藥化學(xué)中間體，它可用于藥物分子瑞美吉泮的生產(chǎn)。